Bookcover of Toxicity studies of Norfloxacin, a fluoroquinolone in rats
Booktitle:

Toxicity studies of Norfloxacin, a fluoroquinolone in rats

LAP LAMBERT Academic Publishing (2014-10-08 )

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ISBN-13:

978-3-659-61201-5

ISBN-10:
3659612014
EAN:
9783659612015
Book language:
English
Blurb/Shorttext:
In acute oral toxicity LD50 value obtained was 4541.1067 mg/ kg. In repeated dose 28 day subacute oral toxicity study, hematological parameters viz., TEC, Hb, Hct and TLC showed significant decreased level in treated groups. Similarly biochemical parameters viz., aspartate aminotransferase, alanine aminotransferase, BUN, creatinine showed significant increased level in treated groups. There was a significant decrease in body weight gain in treated groups. Satellite high dose group animals showed partial recovery in terms of haematological, biochemical parameters and body weight gain after cessation of norfloxacin administration. Histopathology of both male and female rats revealed toxic effect of norfloxacin on liver, kidney, heart, spleen and intestines. Satellite high dose group showed recovery to normalcy in histopathological study.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Rashmi R., Jagadeesh S. Sanganal, Shridhar N. B.
Number of pages:
136
Published at:
2014-10-08
Stock:
Available
Category:
Veterinary medicine
Price:
61.90 €
Keywords:
Norfloxacin, Acute oral toxicity study, Subacute oral toxicity study, sodium acetate buffer, female rats

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