Bookcover of Three Models of Huntington''s Disease
Booktitle:

Three Models of Huntington''s Disease

The Neuropathological Investigations of Transgenic Murine Models of Disease

LAP LAMBERT Academic Publishing (2009-11-24 )

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ISBN-13:

978-3-8383-2884-3

ISBN-10:
3838328841
EAN:
9783838328843
Book language:
English
Blurb/Shorttext:
Huntington''s disease (HD) is a purely genetic neurodegenerative disorder affecting approximately 1 in 10,000 people. It is most commonly associated with excessive involuntary movement, or chorea, combined with varying degrees of other motor, psychiatric and cognitive disturbances. Identification of the mutation in the HD gene prompted the generation of several transgenic mouse models. HD is but one of a family of at least 9 triplet repeat disorders, all of which exhibit protein aggregation by a similar mechanism. The understanding of one disease is therefore of importance to the understanding of them all. This work aims to be a comprehensive comparative study of three very different mouse models of HD elucidating the pathological changes that precede and accompany the disease process.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Aysha S. Raza
Number of pages:
304
Published at:
2009-11-24
Stock:
Available
Category:
Clinical disciplines
Price:
79.00 €
Keywords:
Neuroscience, neurodegeneration, Neuropathology, Transgenic models, Huntington''s disease, brain, Neuron, neuronal intranuclear inclusion, dark cell degeneration, neuronal cachexia

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