Bookcover of The GABAergic System
Booktitle:

The GABAergic System

A Metabolomic Approach

VDM Verlag Dr. Müller (2009-08-19 )

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ISBN-13:

978-3-639-17478-6

ISBN-10:
363917478X
EAN:
9783639174786
Book language:
English
Blurb/Shorttext:
Despite modern technology, little is known about brain function and its relationship to the underlying neuronal activities in the presence of a mental workload. This strongly stands when attempting to dissect the nature of the functional responses to inhibitory modulation in the brain.This book therefore presents a metabolomic approach to study inhibitory GABAergic neurotransmission using Nuclear Magnetic Resonance Spectroscopy. It encompasses a metabolic fingerprint which maps targeted activity of the GABAergic system using multivariate statistics. This book introduces a new approach to the study of brain function, a methodology which has great potential for use in high throughput screening of new pharmacological tools. This also provides a fundamental basis for the interpretation of in vivo pharmacological and functional magnetic resonance imaging studies: GABAergic modulation has distinct metabolic patterns which should be taken into account when evaluating functional imaging data involving modulation of neuronal inhibition.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
By (author) :
Fatima Nasrallah
Number of pages:
196
Published at:
2009-08-19
Stock:
Available
Category:
Biochemistry, biophysics
Price:
68.00 €
Keywords:
GABA, Neurochemistry, Metabolomic, spectroscopy, Metabolic, brain

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