Bookcover of Stem cell and growth factor delivery vehicles for cartilage repair
Booktitle:

Stem cell and growth factor delivery vehicles for cartilage repair

Co-delivery of growth factor-loaded microspheres and human adipose stem cells in a gel matrix for cartilage repair

LAP LAMBERT Academic Publishing (2012-10-17 )

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ISBN-13:

978-3-659-22981-7

ISBN-10:
3659229814
EAN:
9783659229817
Book language:
English
Blurb/Shorttext:
Co-delivery of embedded growth factor-loaded microspheres and adult stem cells in a hydrogel matrix was studied for its potential as a cell-based therapeutic strategy for cartilage regeneration in partial thickness chondral defects. A photopolymerizable N-methacrylate glycol chitosan (MGC) was employed to form an in situ gel that was embedded with two formulations of growth factor-loaded microspheres and human adipose-derived stem cells (ASC). The polymeric microspheres were used as a delivery vehicle for the controlled release of growth factors to stimulate differentiation of the ASC towards the chondrocyte lineage. Bone morphogenetic protein-6 (BMP-6) and transforming growth factor-b3 (TGF-b3) were delivered at 5 ng/day at highly bioactive states. The ratio of collagen type II to I per cell was significantly higher for ASC chondrogenesis induced by the sustained release of BMP-6 and TGF-b3 in MGC gels than that of non-induced ASC or with soluble growth factor administration in the culture media. Thus, the co-delivery of growth factor-loaded microspheres and ASC in MGC gels successfully induced ASC chondrogenesis and is a promising strategy for cartilage repair.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Abby Sukarto
Number of pages:
220
Published at:
2012-10-17
Stock:
Available
Category:
Other
Price:
79.00 €
Keywords:
Cartilage, Hydrogels, Cell encapsulation, human adipose-derived stem cells, controlled release growth factors, chondrogenesis, polymeric microspheres

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