Bookcover of Simultaneous estimation of Atorvastatin, Clopidogril & Aspirin
Booktitle:

Simultaneous estimation of Atorvastatin, Clopidogril & Aspirin

Simultaneous estimation of Atorvastatin, Clopidogril and Aspirin by using UV-VIZ Spectroscopy

LAP LAMBERT Academic Publishing (2016-08-24 )

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ISBN-13:

978-3-659-94281-5

ISBN-10:
3659942812
EAN:
9783659942815
Book language:
English
Blurb/Shorttext:
Atorvastatin [R-(R*,R*)]-2-(4-fluorophenyl)-ß, -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenyl amino)carbonyl]-1H-pyrrole 1-heptanoic acid an Anti-hyperlipidemia and Clopidogrel (2-Chloro phenyl, 6-7 dihydro4H thieno [3,2-c]pyridine-5-yl)acetic acid is an Anti-platelet drug and Aspirin (2-Acetoxy benzoic acid) an NSAIDs. This paper presents two methods i.e. first derivative spectrophotometery and multicomponent spectrophotometery for simultaneous estimation of these three drugs combination in pharmaceutical formulations. The first derivative amplitudes at 276, 226 and 222 nm were utilized for simultaneous estimations. The multicomponent amplitudes at 247, 220 and 235 nm were utilizatied. Proper selection of wavelength for estimations of one drug by other in derivative spectra and multicomponent lead to successful development of methods for simultaneous estimation. The results of analysis were validated statistically that included parameters such as precision, LOD, LOQ, recovery and robustness. Both methods were simple, economical, accurate, reproducible and precise.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Sunil Singh
Number of pages:
88
Published at:
2016-08-24
Stock:
Available
Category:
Pharmacy
Price:
35.90 €
Keywords:
validation, Atorvastatin, Clopidogril, aspirin

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