Bookcover of Selectin-mediated Leukocyte Adhesion During the Immune Response
Booktitle:

Selectin-mediated Leukocyte Adhesion During the Immune Response

Experimental and computational studies of white blood cell recruitment to the vascular wall

VDM Verlag Dr. Müller (2008-10-29 )

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ISBN-13:

978-3-639-09454-1

ISBN-10:
3639094549
EAN:
9783639094541
Book language:
English
Blurb/Shorttext:
Selectins are cell adhesion molecules that initiate recruitment of white blood cells to targeted sites on the blood vessel wall. This process is necessary for numerous immune functions, including inflammation, lymphocyte homing, and bone marrow replenishment after transplantation. Cell recruitment proceeds via a multi-step process, with selectin-mediated rolling followed by integrin-mediated firm adhesion. This book extends current knowledge of leukocyte adhesion by examining selectin-mediated adhesion in both experimental and computational studies. Selectin-ligand interactions were experimentally characterized using a yeast display system, in which E-selectin-expressing yeast were perfused over ligand-bearing surfaces. Structure-function relationships in selectin ligands were studied using cell-free rolling experiments, in which ligand-coated microspheres were perfused over L-selectin substrate. Finally, the roles of selectins and integrins in cell adhesion were investigated using adhesive dynamic (AD) simulations. The model successfully reproduces in vivo data, and predicts synergistic functions of the two receptors in mediating leukocyte adhesion.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
By (author) :
Bhatia Sujata K.
Number of pages:
220
Published at:
2008-10-29
Stock:
Available
Category:
Technology
Price:
79.00 €
Keywords:
Adhesion, selectin, Integrin, leukocyte, Inflammation, lymphocyte, Neutrophil, Rolling

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