Bookcover of Properties of p20, a yeast eIF4E‐binding protein
Booktitle:

Properties of p20, a yeast eIF4E‐binding protein

Regulation of eukaryotic translation initiation

LAP LAMBERT Academic Publishing (2015-04-27 )

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ISBN-13:

978-3-659-68504-0

ISBN-10:
3659685046
EAN:
9783659685040
Book language:
English
Blurb/Shorttext:
The yeast phosphoprotein p20 is a modulator of translation and shares with mammalian 4EBPs a conserved eIF4E-binding motif. In this book, six more phosphorylation sites have been found on p20 by means of proteomics and a non-phosphorylatable p20 isoform has been established. Moreover, a phenotype of p20 is demonstrated while differences between derivates of two genetically diverse laboratory yeast strains became visible. Investigation of p20 mutants under several stress conditions leads to the conclusion that mutations in p20 affecting its eIF4E binding result in p20 degradation and to a phenotype in a filamentous strain. Furthermore the influence of non-phosphorylatable or several other p20 mutants on translation of reporter mRNAs as well as p20ʼs effect on localisation of eIF4E are shown in this work.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Daniela Ross
Number of pages:
84
Published at:
2015-04-27
Stock:
Available
Category:
Biochemistry, biophysics
Price:
39.90 €
Keywords:
yeast, Translation initiation

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