Bookcover of Oxygen Activation, Oxidative Stress and Human Health
Booktitle:

Oxygen Activation, Oxidative Stress and Human Health

LAP LAMBERT Academic Publishing (2012-12-11 )

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ISBN-13:

978-3-8433-8073-7

ISBN-10:
3843380732
EAN:
9783843380737
Book language:
English
Blurb/Shorttext:
I have investigated the oxygen activation mechanism in biological oxygenases on the basis of the ligand field theory, and have established new concept on the oxygen activation by metal ions, which is quite different from those reported in many papers published hitherto. According to my new concept, it is quite clear that the responsibility of the hydroxyl radical or free singlet oxygen is negligible as a “reactive oxygen species” in the biological systems, and that oxidative stress due to the iron ions is induced by the unique properties of the iron ions, i.e., some of the water-soluble non-transferrin-bound iron (NTBI) react with oxygen or hydrogen peroxide, changing these molecules to those exhibiting electrophilicity, similar to singlet oxygen. Based on these results, I have synthesized new super-polyphenols, and found that some of these compounds can eliminate NTBI effectively from the plasma. In addition to this, we have observed that some derivatives of our super-polyphenols exhibits high ability for the removal of H2O2 and phosphoric acid from the solution.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Yuzo Nishida
Number of pages:
140
Published at:
2012-12-11
Stock:
Available
Category:
Biochemistry, biophysics
Price:
59.00 €
Keywords:
oxidative stress, neurodegeneration, Iron toxicity, Oxygen activation

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