- Natural-, Medical- , Computer Sciences, Technology
- Biology
- Non-canonical pre-TCR signaling during T cell development
- Bookcover of Non-canonical pre-TCR signaling during T cell development
- Booktitle:
-
Non-canonical pre-TCR signaling during T cell development
LAP LAMBERT Academic Publishing (2016-03-23 )
eligible for voucher
- ISBN-13:
978-3-659-85761-4
- ISBN-10:
- 3659857610
- EAN:
- 9783659857614
- Book language:
- Blurb/Shorttext:
- T cells undergoing maturation in the thymus need to receive a pre-TCR-delivered signal to undergo β-selection and develop further properly. The pre-TCR is composed of a constitutively expressed pre-Tα (pTα) chain and a de novo expressed TCRβ chain. A productive recombination of the TCRβ chain is mandatory to overcome the first checkpoint that controls T cells survival. However, in a very low but consistent extent, thymocytes lacking a canonical pre-TCR can differentiate further. We show that thymocytes lacking a classical pre-TCR can survive and differentiate to later developmental stages. Besides, signaling through a pTα-less TCR is enough to achieve Ca2+ influx and NF-κB activation. In addition, we demonstrate that the mechanisms underlying cell death of thymocytes in conditions of proteasome inhibition are in great extent independent of NF-κB activation and pre-TCR or TCR signaling, and are rather dependent on triggering the pro-apoptotic terminal UPR.
- Publishing house:
- LAP LAMBERT Academic Publishing
- Website:
- https://www.lap-publishing.com/
- By (author) :
- Damian Maseda Caballero
- Number of pages:
- 104
- Published at:
- 2016-03-23
- Stock:
- Available
- Category:
- Biology
- Price:
- 39.90 €
- Keywords:
- B cell, immunology, inflammation, proteasome, T cell, T cell receptor, Thymus
