Bookcover of New Platinum tumour active compounds
Booktitle:

New Platinum tumour active compounds

New platinum antitumor drugs

LAP LAMBERT Academic Publishing (2012-06-19 )

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ISBN-13:

978-3-8484-4004-7

ISBN-10:
3848440040
EAN:
9783848440047
Book language:
English
Blurb/Shorttext:
Four mononuclear trans-planaramineplatinum complexes code named JH1, JH2, JH3, and JH4, and two trinuclear complexes code named JH5 and JH6 have been prepared and characterised based on elemental analyses, IR, mass and 1H NMR spectral measurements. The activity of the compounds against human ovarian cancer cell lines A2780, A2780cisR and A2780ZD0473R, cell uptake, level of binding with DNA and nature of interaction with pBR322 plasmid DNA and salmon sperm DNA have been determined. Among the mononuclear complexes JH1 is found to be most active: four times more active than cisplatin in the resistant cell line A2780cisR and six times more active in the resistant cell line A2780ZD0473R. Between the two trinuclear compounds, JH6 is found to be more active than JH5 in all three ovarian cancer cell lines A2780, A2780cisR and A2780ZD0473R. JH6 is also more active than cisplatin in all the ovarian cell lines A2780, A2780cisR and A2780ZD0473R: two times more active than cisplatin in the parent cell line A2780, three times more active in the resistant cell line A2780cisR and about two times more active in the resistant cell line A2780ZD0473R.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Jehad Al-Shuneigat
Number of pages:
296
Published at:
2012-06-19
Stock:
Available
Category:
Medicine
Price:
79.00 €
Keywords:
cancer, DNA binding, Platinum anticancer drugs, formation of inter- and intra-strand adducts of poly and mono-nuclear complexes, Syntheses of trinuclear platinum complexes, Activation of trans-platinum complexes

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