Bookcover of Involvement of Reactive Nitrogen Species and NF-κB in colon cancer
Booktitle:

Involvement of Reactive Nitrogen Species and NF-κB in colon cancer

LAP LAMBERT Academic Publishing (2013-08-05 )

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ISBN-13:

978-3-659-43377-1

ISBN-10:
3659433772
EAN:
9783659433771
Book language:
English
Blurb/Shorttext:
The reactive nitrogen species peroxynitrite is a product of the reaction of nitric oxide with superoxide. This powerful oxidant has been proposed to contribute to the pathology of a large variety of diseases associated with increased inflammation and cancer development by its ability to oxidize and nitrate a variety of macromolecules. The transcription factor NF-κB is a predominant player in inflammatory and carcinogenic processes and has been found to play a major role in the transition from chronic inflammation to cancer initiation. In this study the molecular mechanisms by which NF-κB is activated under nitrative stress in a human colon cancer cell line and in colitis and human colon cancer sections of patients were investigated. The in vitro studies showed a dynamic, kinetic, and intensity activation of NF-κB caused by peroxynitrite, lead to an aberrant and belated pathway compared to the canonical activation by TNF-α. It occurred in a simultaneous dual mechanism: IKK dependent, by which p38 MAPK was found to be involved, and IKK independent. The clinical studies supported these findings with high activation of NF-kB and its target genes in colitis and colon cancer sections.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Einat Gochman, Abraham Z. Reznick, Jamal Mahajna
Number of pages:
144
Published at:
2013-08-05
Stock:
Available
Category:
Biochemistry, biophysics
Price:
36.90 €
Keywords:
cancer, Inflammation, Phosphorylation, NF-κB, Nitration, IKK, p38, reactive nitrogen species, peroxynitrite, IκBα

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