Bookcover of Insight into Host Adaptation of Enterohepatic Helicobacter Bacteria
Booktitle:

Insight into Host Adaptation of Enterohepatic Helicobacter Bacteria

A molecular study of the response of Helicobacter hepaticus to bile, and the effect of Helicobacter bilis on human hepatoma cells

VDM Verlag Dr. Müller (2010-07-14 )

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ISBN-13:

978-3-639-27414-1

ISBN-10:
3639274148
EAN:
9783639274141
Book language:
English
Blurb/Shorttext:
Enterohepatic Helicobacter species are emerging infectious disease agents. Infection of the enterohepatobiliary tract of several mammals by these bacteria results in various pathological disorders. The adaptation of Helicobacter hepaticus to human factors such as bile was investigated using proteomics and transcriptomics. Ninety-one different proteins were identified in the responses of H. hepaticus to human, porcine and bovine bile. These proteins participate in several key cellular processes including DNA replication; protein transcription, translation and folding; oxidative stress response; motility; virulence; and metabolism. In particular, the bacteria deployed several strategies such as inhibition of the TCA cycle and the electron transport chain as well as iron sequestration to ensure control of the levels of hydroxyl radicals. The responses of human HEp-2 and Huh7-derived cell-lines to H. hepaticus and Helicobacter bilis, respectively, were also investigated.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
By (author) :
Arinze Okoli
Number of pages:
280
Published at:
2010-07-14
Stock:
Available
Category:
Microbiology
Price:
79.00 €
Keywords:
Proteome, Transcriptome, informatics, Campylobacterales, Helicobacter, Hepaticus, Bilis, HEp-2, Huh7, 2D-PAGE

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