Bookcover of Influence of capacity on four different sulfobetaine stationary phases
Booktitle:

Influence of capacity on four different sulfobetaine stationary phases

Zwitterionic Hydrophilic Interaction Liquid Chromatography

Scholars' Press (2015-06-08 )

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ISBN-13:

978-3-639-51601-2

ISBN-10:
363951601X
EAN:
9783639516012
Book language:
English
Blurb/Shorttext:
A number of covalently bonded zwitterionic stationary phases with inner quaternary amines and outer sulfonic acids in varying capacities was synthesized based on poly (styrene-DVB) particles by graft polymerization. The different spacer lengths and capacities are used as an investigative tool, for the retention behavior of the inorganic anions in ZIC and ZIC-HILIC modes. The results of variations of acetonitrile content, buffer concentration and mobile phase pH show that pharmaceuticals can be separated based on hydrophilic, hydrophobic and anion/cation-exchange interactions between the stationary phase and analyte. The pharmaceutical deferoxamine mesylate (DFOM) is a chelating agent which forms complexes with multiple charged metal ions of biological importance (Fe3+, Al3+) and other metals. We could demonstrate that the sulfobetaine exchangers are able to separate the Fe(III)-DFOM and Al(III)-DFOM complexes by IC-ICP-AES. Excess adsorption isotherms of water from acetonitrile were measured for ten zwitterionic stationary phases (eight sulfobetaine exchangers have been prepared and two commercially available stationary phases) using the minor disturbance method.
Publishing house:
Scholars' Press
Website:
http://www.scholars-press.com
By (author) :
Ashraf Saad Rasheed, Andreas Seubert
Number of pages:
180
Published at:
2015-06-08
Stock:
Available
Category:
Chemistry
Price:
79.90 €
Keywords:
Zwitter ion chromatography, Hydrophilic ion chromatography, Sulfobetaine, Capacity, pharmaceutical, Excess adsorption isotherm

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