Bookcover of Gelrite-Based In situ Gel for the Nasal Delivery
Booktitle:

Gelrite-Based In situ Gel for the Nasal Delivery

Formulation & Characterization of In-situ Gels for Nasal Delivery of Salbutamol Sulfate

LAP LAMBERT Academic Publishing (2014-11-20 )

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ISBN-13:

978-3-659-63969-2

ISBN-10:
3659639699
EAN:
9783659639692
Book language:
English
Blurb/Shorttext:
Salbutamol sulfate (SS), a direct acting sympathomimetic; used for the treatment of acute and chronic asthma, was formulated as gelerite® in-situ gels. SS in-situ gels (2% w/w) were prepared at concentration of gellan gum 0.2%, 0.4% and 0.8% w/v with methyl paraben (0.05%) as preservative. In-vitro release in simulated nasal fluid showed relatively fast release and release kinetics followed diffusion kinetic model. In-vivo mucoadhesiveness test performed in rats, showed prolonged mucociliary transport time from 5 min (control solution) to 16.5 and 19.5 minutes for formulations containing 0.4% & 0.8% respectively. In-situ gels have demonstrated an adequate safety to the nasal mucosa of rats. The 0.4 % in-situ gel remained liquid for 6 months without occurrence of turbidity or gelation at storage temperature conditions. Statistical analysis revealed non-significant difference in content uniformity or release compared to the fresh ones. In-situ gel is a promising approach for the intranasal delivery of SS, combines the advantage of a solution , administration convenience and exact dosing with favorable residence time and expected improved drug absorption. .
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Ragwa Farid Mansour, Mohamed Ahmed Etman, Abd-Elazim Rafaat Ebian
Number of pages:
68
Published at:
2014-11-20
Stock:
Available
Category:
Pharmacy
Price:
39.90 €
Keywords:
In-situ Gel, Gelerite, Nasal Delivery, Salbutamol Sulfate, Mucociliary transport time, Nasal Deposition

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