Bookcover of Formulation and Evaluation of an In Situ Gel for Ocular Delivery
Booktitle:

Formulation and Evaluation of an In Situ Gel for Ocular Delivery

LAP LAMBERT Academic Publishing (2013-09-19 )

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ISBN-13:

978-3-659-46191-0

ISBN-10:
3659461911
EAN:
9783659461910
Book language:
English
Blurb/Shorttext:
Norfloxacin ophthalmic solution has been shown to be effective ocular infections and may be used in patients with chronic conjunctivitis or ocular irritation. Norfloxacin in-situ gel was prepared using various concentrations of polymers such as Carbopol-940 (0., 0.2, 0.3 0.4and 0.5% w/v), HPMC- E50LV (1.5 % w/v), HPMC E4M (0.6 %w/v) and HPMC K4M (0.5% w/v) by pH triggered gelling system with an objectives of increasing contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy of drug. The prepared in-situ gels were then evaluated for their visual appearance, clarity, pH, drug content analysis, in-vitro gelation (Gelling capacity), rheological studies, sterility testing, textureanalysis and in-vitro drug release studies. It is evident from these studies that, formed polymeric in-situ gels had transparent, clear possessing satisfactory gelling capacity. The developed formulation was light yellow in colour, therapeutically efficacious, stable, non irritant with sustained release of drug.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Sachinkumar Patil, Shitalkumar Patil, Amit Jagdale
Number of pages:
100
Published at:
2013-09-19
Stock:
Available
Category:
Other
Price:
54.90 €
Keywords:
in situ gel, Ocular Delivery, anticonjectival drug

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