Bookcover of Development of Sustained Release Tablet containing Antidiabetic Agent
Booktitle:

Development of Sustained Release Tablet containing Antidiabetic Agent

LAP LAMBERT Academic Publishing (2013-08-25 )

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ISBN-13:

978-3-659-27459-6

ISBN-10:
3659274593
EAN:
9783659274596
Book language:
English
Blurb/Shorttext:
The overall objective of the present work was to develop an oral sustained release Metformin tablet prepared by direct compression method using Hydroxypropylmethyl cellulose and Xanthan gum in different proportions. Nine formulations (T1-T9) were prepared. All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity and in vitro drug release. The dissolution study was performed as per USP-32 NF-27. The initial burst release was minimized by optimizing the concentration of xanthan gum. Then the concentration of HPMC was varied, keeping the concentration of xanthan gum fixed. From the dissolution study of nine batches, T8 was found to be the optimized batch capable to sustain the drug release for 10 hrs as it follows the dissolution parameter mentioned in USP-32 NF-27. The drug release kinetics shows that the T8 batch followed first order kinetics.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Rajat Kharche
Number of pages:
124
Published at:
2013-08-25
Stock:
Available
Category:
Pharmacy
Price:
54.90 €
Keywords:
Xanthan Gum, metformin HCl, HPMC, Oral Sustained Release, Biguanide

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