Bookcover of Development of Novel Peptide Inhibitors to BAG-1
Booktitle:

Development of Novel Peptide Inhibitors to BAG-1

Applications of Peptidyl-Biomimetics to reduce and eliminate tumor resistance to chemotherapy

LAP LAMBERT Academic Publishing (2014-10-14 )

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ISBN-13:

978-3-659-61692-1

ISBN-10:
3659616923
EAN:
9783659616921
Book language:
English
Blurb/Shorttext:
One of the most challenging aspects of treating tumors with chemotherapy is that the tumors can develop a resistance to the chemotherapy and survive while the rest of the healthy, non-cancerous cells perish. Higher doses of chemotherapy deliver fewer positive results and at the expense of greater side effects. The purpose of this book is to identify and exploit a weakness at the molecular level of the anti-apoptotic pathway utilized by cancer cells to turn off the "triggered cell death" mechanism of apoptosis and survive chemotherapy. We specifically target the interaction between the anti-apoptotic protein Bcl-2 Associated Athanogene (BAG-1) and the 70-kilodalton Heat Shock Protein (HSP-70) that is suspected of driving the chemotherapeutic resistance, and seek to disrupt that interaction via peptidyl-biomimetically engineered peptides that are predicted via an in-house computational software named "Contact" and experimentally verified via Biacore (c) binding assays. The program "Contact" is now available for free download at http://www.engineering.vcu.edu/proteinengineering/
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Jonathan Brunn
Number of pages:
92
Published at:
2014-10-14
Stock:
Available
Category:
Biochemistry, biophysics
Price:
54.90 €
Keywords:
BAG-1 HSP-70 peptide inhibitor cancer tumor suppression peptidyl-biomimetics

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