Bookcover of Asymmetric Membrane Capsule- An Osmotic Approach
Booktitle:

Asymmetric Membrane Capsule- An Osmotic Approach

Formulation and Evaluation of Asymmetric Membrane Capsule Osmotic Pump of Gliclazide

LAP LAMBERT Academic Publishing (2012-11-15 )

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ISBN-13:

978-3-659-30089-9

ISBN-10:
3659300896
EAN:
9783659300899
Book language:
English
Blurb/Shorttext:
The aim of this study was to demonstrate that the asymmetric membrane capsule can be used to deliver a poorly water soluble drug with a pH sensitive solubility such as gliclazide. In order to obtain the desired delivery duration, the drug was solubilized with the use of a pH-controlling excipient. The capsule wall membrane was made by a phase inversion process, in which asymmetric membrane was formed on glass mold pins by dipping the mold pins into a coating solution containing a polymeric material followed by dipping into a quench solution. This study evaluates the influence of coating formulation that was cellulose acetate (CA), ethylcellulose (EC), and plasticizer (glycerin and PEG 600). Results show capsule that made by CA with glycerol and PEG 600, which appear in asymmetric structure and are able to release gliclazide(GLZ) in significant percentage.Based on the result, influence of core formulation variables, including D-mannitol, sodium bicarbonate and the added amount of SLS were examined on the release of GLZ. It was found that HPMC 15cp was suitable to be a thickening agent and both added amount of HPMC and SLS showed a comparable and profoundly positive effect.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Sandipkumar Teraiya, Shrujal Patel, Bhargav Jayswal
Number of pages:
156
Published at:
2012-11-15
Stock:
Available
Category:
Pharmacy
Price:
59.00 €
Keywords:
Cellulose acetate, Anti-diabetic Drug, Asymmetric Membrane Capsule, Gliclazide, Novel Drug Delivery System, Ethyl Cellulose, Osmotic Pump, Osmotic Drug Delivery System, CPOP

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