Bookcover of A Hybrid Core-Shell rhOP-1 Nanoparticulate Delivery System
Booktitle:

A Hybrid Core-Shell rhOP-1 Nanoparticulate Delivery System

A Hybrid Core-Shell rhOP-1 Nanoparticulate Delivery System for Enhanced New Bone Regeneration in Distraction Osteogenesis

LAP LAMBERT Academic Publishing (2010-07-26 )

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ISBN-13:

978-3-8383-7700-1

ISBN-10:
3838377001
EAN:
9783838377001
Book language:
English
Blurb/Shorttext:
Distraction osteogenesis (DO) is a prevalent surgical technique for the correction of congenital orthopaedic deformities and craniofacial developmental conditions. Yet, clinical benefits continue to be limited by a number of complications mainly as a result of the protracted treatment time during which the fixator has to be kept in situ until the newly-formed bone in the distracted zone consolidates (or hardens), thus exacerbating significant medical, psychological and socio-economical problems on patients, their families and caregivers. On the other hand, protein therapy particularly with the use of potent osteoinductive cytokines from the TGF-β superfamily has been hailed as the most promising alternative to conventional bone grafts. Currently, rhBMP-2 and rhBMP-7/OP-1 have been approved for their "restricted" clinical use in long bone healing and spinal fusion. Prospective clinical trials have reported variability in results ranging from full bone bridging to no bone union and to optimize the therapeutical outcome, the incorporated high and unsafe dosages of the growth factors timing of release and their application systems necessitate further development.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Ziyad S. Haidar
Number of pages:
304
Published at:
2010-07-26
Stock:
Available
Category:
Biochemistry, biophysics
Price:
79.00 €
Keywords:
controlled drug release, Liposome, Polysaccharide, self-assembly, Alginate, Alkaline Phosphatase, bone morphogenetic protein(s), cell viability, chitosan, core-shell nanoparticles, Bone regeneration, Bone repair, Craniofacial surgery, delivery systems, Orthopaedics, biomaterials, Distraction osteogenesis, osteogenic protein-1, nanoparticles, bone densitometry, histomorphometry, biocompatibility, Foreign body response, Haemocompatibility

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