Capa do livro de Environmental stress response regulator, Nrf2 is a modifier of COPD
Título do livro:

Environmental stress response regulator, Nrf2 is a modifier of COPD

LAP LAMBERT Academic Publishing (2013-10-04 )

Books loader

Omni badge Apto para vale
ISBN- 1 3:

978-3-659-46751-6

ISBN- 1 0:
3659467510
EAN:
9783659467516
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
Nrf2 is a pleiotropic master transcription factor, which responds to diverse oxidative and electrophilic environmental stresses that circumvent Nrf2's repression and proteasomal degradation by its repressor, Keap1 by oxidation of Keap1. Nrf2 then translocates to the nucleus, and activates a cytoprotective gene pathway network of over 2000 genes. Nrf2 activated responses provide protection against chemical carcinogenesis, chronic inflammation, neurodegeneration, asthma, sepsis and emphysema as discussed here, both in murine models and human patients. Nrf2 regulates the expression of a plethora of genes that detoxify oxidants and electrophiles and repair or remove damaged macromolecules, such as through proteasomal processing to reduce ER stress and consequent cell death, both involved in lung injury. Furthermore, Nrf2 activators, such as Sulforaphane (a natural supplement from broccoli extract) are demonstrated as supplementary drugs in COPD prevention and treatment along with the highly prescribed, anti-inflammatory glucocorticoids. Nrf2 activation by Sulforaphane accentuates the efficacy of glucocorticoids in COPD patients by decreasing nitrosative stess associated inflammation.
Editora:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
Por (autor):
Deepti Malhotra
Número de páginas:
376
Publicado em:
2013-10-04
Stock:
Disponível
Categoria:
Medicina
Preço:
93.90 €
Palavras chave:
sulforaphane, COPD, Chronic obstructive pulmonary disease, Nrf2, Nfe2l2, UPR, pathobiology, Antioxidant, lung, proteasome, er stress, Cigarette Smoke

Books loader

Adyen::diners Adyen::jcb Adyen::discover Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::alipay Adyen::unionpay Adyen::paypal PayPal Transferência Bancária

  0 produtos no carrinho
Editar carrinho
Loading frontend
LOADING