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Könyv címe:

Tetrahydrobiopterin and nitric oxide synthase regulation

Generation and analysis of endothelial-targeted transgenic mouse lines over-expressing human GTP cyclohydrolase 1

VDM Verlag Dr. Müller (05.06.2009 )

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ISBN-13:

978-3-639-16400-8

ISBN-10:
3639164008
EAN:
9783639164008
Könyv nyelve:
angol
Ismertető:
Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymatic activity appears to be determined by the availability of its cofactor tetrahydrobiopterin (BH4). BH4 bioavailability is limited by oxidative degradation in dysfunctional endothelium, and by alterations in the rate of its biosynthesis, governed by the rate-limiting enzyme GTP cyclohydrolase 1 (GTPCH). In this project novel targeted transgenic mouse lines were generated with endothelial-specific over-expression of human GTPCH. These studies have shown that BH4 bioavailability within the endothelium is essential for maintaining NO synthesis and reducing superoxide production by eNOS in vivo. Modest persistent increases in endothelial cell BH4 concentration by increased biosynthesis are sufficient to maintain NO bioavailability and endothelial function, even in the setting of vascular oxidative stress. These findings suggest that strategies to augment endothelial BH4 levels, either by increased biosynthesis or by reducing BH4 oxidation, may be valuable in preventing and treating vascular disease.
Kiadó:
VDM Verlag Dr. Müller
Weboldal:
http://www.vdm-verlag.de
Szerezte:
Nicholas Alp
Oldalszám:
140
Kiadja:
05.06.2009
Raktárkészlet:
Raktáron
Kategória:
Gyógyszerészet
Ár:
59,00 €
Kulcsszavak:
Vascular biology, nitric oxide synthase, mouse model, Atherosclerosis, tetrahydrobiopterin, Biochemistry

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