Bookcover of Virus-host cell interplay in cancer progression
Booktitle:

Virus-host cell interplay in cancer progression

Understanding the pathogenesis of Kaposi’s sarcoma herpesvirus (KSHV)

LAP LAMBERT Academic Publishing (2012-04-24 )

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ISBN-13:

978-3-659-10515-9

ISBN-10:
3659105155
EAN:
9783659105159
Book language:
English
Blurb/Shorttext:
Human tumor viruses contribute to 15-20% of human cancers worldwide. Kaposi’s sarcoma herpesvirus (KSHV) is an etiological agent for Kaposi’s sarcoma (KS) and two other malignancies. KS is the most common cancer in HIV-infected untreated individuals and remains a primary cause of cancer deaths in many subequatorial African countries as a result of the AIDS pandemic. This book first introduces an unbiased gain-of-function human kinome cDNA screen on KSHV reactivation in infected human cells. By developing a novel 3D cell culture model reflecting the context of virus-host cell interaction, this book further reveals the first lymphatic-specific endothelial-to-mesenchymal transition (EndMT) induced by a human tumor virus, giving rise to infected, invasive cells, and providing the virus a permissive cellular microenvironment for efficient spread of the virus. This book should shed lights on understanding the long-term persistence of oncogenic infectious agents in infected individuals, allowing time for the multi-step tumorigenesis. It should also be especially useful for professionals who are interested in developing targeted therapies to prevent or at least slow down KS progression.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Fang Cheng
Number of pages:
140
Published on:
2012-04-24
Stock:
Available
Category:
Medicine
Price:
59.00 €
Keywords:
Herpesvirus, KSHV, Kaposi’s sarcoma, virus reactivation, endothelial-mesenchymal transition (EndMT), Pim kinase, Notch signaling, virus-host cell interaction, human tumor virus, MT1-MMP

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