Bookcover of Trox-1
Booktitle:

Trox-1

Calcium channel blocker, Voltage-dependent calcium channel, Analgesic

VolvPress (2012-01-01 )

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ISBN-13:

978-613-9-27688-2

ISBN-10:
6139276888
EAN:
9786139276882
Book language:
English
Blurb/Shorttext:
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. TROX-1 is a drug which acts as a potent blocker of the Cav2 type calcium channels. It was developed as a potential analgesic after the discovery that the selective Cav2.2 blocker ziconotide is an active analgesic with similar efficacy to strong opioid drugs but comparatively milder side effects. Unlike ziconotide, TROX-1 is not so selective, and also blocks the Cav2.1 and Cav2.3 calcium channel subtypes, but it has the great advantage of being orally active, whereas ziconotide must be administered , by injection into the spinal fluid. In animal studies of TROX-1, analgesic effects were observed with similar efficacy to such as naproxen or diclofenac, and anti-allodynia effects equivalent to pregabalin or duloxetine.
Publishing house:
VolvPress
Website:
http://www.betascript-publishing.com
Edited by:
Sören Jehoiakim Ethan
Number of pages:
56
Published on:
2012-01-01
Stock:
Available
Category:
Medicine
Price:
29.00 €
Keywords:
Calcium Channel Blocker, Voltage-dependent calcium channel, Trox-1Analgesic

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