Bookcover of The Role of HIV Genetic Pathway in Apoptosis
Booktitle:

The Role of HIV Genetic Pathway in Apoptosis

HIV physiological role in cell death and survival of cells in the human immune system

LAP LAMBERT Academic Publishing (2016-08-08 )

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ISBN-13:

978-3-659-93104-8

ISBN-10:
3659931047
EAN:
9783659931048
Book language:
English
Blurb/Shorttext:
Today, HIV and AIDS is a global problem and epidemic disorders in the world. Every year the number of HIV infected individuals increases. Many studies have been done a cure for HIV, but the treatment is appropriate and decisive undiscovered. In this book, the physiological role of HIV in cell death was studied.Apoptosis of uninfected bystander cells is a key element of HIV pathogenesis and believed to be the driving force behind the selective depletion of CD4+ T cells leading to immunodeficiency. While several viral proteins have been implicated in this process the complex interaction between Env glycoprotein expressed on the surface of infected cells and the receptor and co-receptor expressing bystander cells has been proposed as a major mechanism. HIV-1 utilizes CD4 as the primary receptor for entry into cells; however, it is the viral co-receptor usage that greatly influences CD4 decline and progression to AIDS. This phenomenon is relatively simple for X4 viruses, which arise later during the course of the disease, are considered to be highly fusogenic, and cause a rapid CD4+ T cell decline. However, in contrast, R5 viruses in general have a greater transmissibility, are encount
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Shahin Asadi
Number of pages:
164
Published on:
2016-08-08
Stock:
Available
Category:
Genetics
Price:
64.90 €
Keywords:
AIDS, apoptosis, CCR5, fusion, HIV, bystander, Env, immune activation, hemifusion, gp41

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