Bookcover of The Merozoite Surface Protein 1 of Plasmodium falcipurum
Booktitle:

The Merozoite Surface Protein 1 of Plasmodium falcipurum

Interaction with the Surface of Human Erythrocytes and with Surface Proteins MSP-6 and MSP-7

LAP LAMBERT Academic Publishing (2012-06-18 )

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ISBN-13:

978-3-8443-1457-1

ISBN-10:
3844314571
EAN:
9783844314571
Book language:
English
Blurb/Shorttext:
Binding of merozoite proteins to erythrocyte during invasion is a critical step. However, little is known about interactions occurring during merozoite invasion of erythrocytes or complex formation of merozoite surface proteins among themselves.One such important merozoite proteins thought to play a crucial role during invasion of RBCs is Merozoite surface protein 1 (MSP-1), a potential candidate for blood stage vaccine development. In this work, an in vitro interaction assay of MSP-1 with human erythrocytes is described to investigate which subunit of MSP-1 bind to Erythrocytes. Although the specificity of the binding is not clear, our data indicates p38 and p42 appears to interact with erythrocytes. Taken together our data suggest that MSP-1 by itself might not be an initial interaction partner for erythrocytes. Interestingly, our data from association study between MSP-1 and MSP-6 performed in this work clearly indicate that hMSP-6 interacts with MSP-1 complexes as long as p38 is present making this subunit the most important interaction partner. Moreover, we also fine map a stretch of 51 amino acids in MSP-6 responsible for the interaction with MSP-1.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Zeleke Mekonnen
Number of pages:
76
Published on:
2012-06-18
Stock:
Available
Category:
Clinical disciplines
Price:
49.00 €
Keywords:
Malaria, erythrocytes, Merozoite Surface Protein 1, Plasmodium falcipurum, MSP6, MSP7

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