Bookcover of Systems Biology Approaches in Infectious Diseases
Booktitle:

Systems Biology Approaches in Infectious Diseases

Host Pathways Modulating Differential Response to Invasive Group A Streptococcal Sepsis

LAP LAMBERT Academic Publishing (2011-09-26 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-8465-1053-7

ISBN-10:
384651053X
EAN:
9783846510537
Book language:
English
Blurb/Shorttext:
Epidemiological and genetic studies showed that severity of invasive group A streptococcal (GAS) sepsis is influenced by interactions of genetic factors of both bacteria and host. Systems biology approaches presented shed light on host mechanisms of differential response to invasive GAS sepsis. Using genome-wide association studies, we found association between differential susceptibility to GAS sepsis and quantitative trait loci (QTL) on mouse Chr 2 and X. Genes within these QTLs were prioritized based on bioinformatics and qPCR to explore mechanisms of host differential susceptibility. Collectively, data suggested that prostaglandin and interleukin 1 signaling pathways act as key modulators of a network of genes involved in immune responses to GAS sepsis. In addition, genome-wide transcriptome studies showed that pathways involving activation of interleukin 10 production and signaling are likely to be associated with resistance to infection. Despite differences between mouse and human immune systems, systems biology approaches results using mice corresponded well with results obtained from human studies demonstrating the power of this approach and better translation to humans.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Nourtan Abdeltawab
Number of pages:
168
Published on:
2011-09-26
Stock:
Available
Category:
Genetics
Price:
68.00 €
Keywords:
Systems genetics, Recombinant inbred mice, Streptococcus pyogenes, Gram positive sepsis, Genetics of susceptibility to infection, QTL mapping, Genome-wide association Studies, Immunogenetics of Infectious Diseases, systems biology, Bioinformatics

Books loader

Newsletter

Adyen::diners Adyen::jcb Adyen::discover Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Adyen::paypal Paypal CryptoWallet Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING