Bookcover of Synthesis of Novel Quinazolinone-Benzothiazole Hybrid Compounds
Booktitle:

Synthesis of Novel Quinazolinone-Benzothiazole Hybrid Compounds

LAP LAMBERT Academic Publishing (2016-08-23 )

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ISBN-13:

978-3-659-94189-4

ISBN-10:
3659941891
EAN:
9783659941894
Book language:
English
Blurb/Shorttext:
Some new amino substituted quinazoline compounds were synthesized and evaluated for their anticancer activity at National Cancer Institute (NCI), U.S.A. Among the synthesized nine compounds, two were selected for single high dose screening (10-5 M) in full 60 cell panel. Among the selected compounds, 2-benzamido-N-(benzo[d]thiazol-2-yl)benzamide 4 exhibited significant anticancer activity against non-small cell lung cancer NCI-H23, colon cancer HCT-15, CNS cancer SF-539, melanoma SK-MEL-5, ovarian cancer OVCAR-8, renal cancer ACHN, prostate cancer PC-3 and breast cancer MCF7 with inhibition rate of 97.82%, 99.67%, 99.21%, 90.75%, 99.21%, 99.31%, 97.23% and 93.29% respectively. This compound was selected for testing under five dose level screening against 60 cancer cell lines. The results of five dose assay revealed significant anticancer activity of this compound against almost all cancer cell lines.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Vikrant Abbot, Varun Bhardwaj, Poonam Sharma
Number of pages:
80
Published on:
2016-08-23
Stock:
Available
Category:
Pharmacy
Price:
35.90 €
Keywords:
medicinal chemistry

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