Bookcover of Role of CD4 T cells in Friend Retroviral Infection
Booktitle:

Role of CD4 T cells in Friend Retroviral Infection

Scholars' Press (2015-05-04 )

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ISBN-13:

978-3-639-76225-9

ISBN-10:
3639762258
EAN:
9783639762259
Book language:
English
Blurb/Shorttext:
The Friend retroviral (FV) model is used here to investigate the role of CD4 T (Th) cells in recovery from acute FV infection. Depletion of Th cells in high recovery mice leads to fatal erythroleukemia owing to high viral load. CD8 T-cell dependent early recovery from FV infection is Th cell-independent but long-term maintenance of effector and memory CD8 T cells requires Th cell help. Moreover, Th cell help is essential for production of neutralizing antibodies by B cells in response to FV. The peak FV-specific Th cell responses is far greater in magnitude in high recovery mice than intermediate recovery mice, which differ in their MHC-II background. Effector Th cells are able to produce anti-viral IFN-γ to reduce viral load only until 3 weeks post infection and subsequently lose their anti-viral effector functions due to the presence of Regulatory T (Treg) cells. Depletion of Treg cells increases the frequency of IFN-γ producing FV-specific Th cells and decreases the viral load further in the infected mice. Considered together, our findings imply that therapeutic manipulation of Treg / Th – cell number and/or function could improve immune control of retroviral infections.
Publishing house:
Scholars' Press
Website:
http://www.scholars-press.com
By (author) :
Savita Nair
Number of pages:
144
Published on:
2015-05-04
Stock:
Available
Category:
Biology
Price:
67.90 €
Keywords:
CD4 T cells, Friend retrovirus, immunity

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