Bookcover of Reinventing The Breast Cancer
Booktitle:

Reinventing The Breast Cancer

A System Biology Approach

LAP LAMBERT Academic Publishing (2011-04-01 )

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ISBN-13:

978-3-8443-2304-7

ISBN-10:
384432304X
EAN:
9783844323047
Book language:
English
Blurb/Shorttext:
Cancer being a highly complex combination of diseases, it can be studied and understood better by the complex networks in System/Network biology. Here is a novel step to study the relation between drug target network and the corresponding drug network using the advanced concept of proteomics and systems biology and to develop an effective strategy for cancer prevention.104 antimutagens were collected from literature survey. Of this only 81 structure were available and taken from the Pubchem database. The PDB ids of the Breast cancer genes were taken. Docking was performed with the help of Quantum docking software and the docking scores were obtained. The list of gene ids obtained is loaded into the VISANT application. From the data obtained and the various analysis done the antimutagen Beta-Sitosterol obtained from the Black cumin Seeds (Nigella Sativa) shows least RMSD value with the protein 2I1J corresponding to the gene UTP14A indicating that Breast cancer specific drugs are specific for the particular disease gene and not random among the networks. The ligands (Antimutagens) show good response to the specific type of cancer.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Amrendar kumar, Abhilahsa Singh, Biplab Bhattacharjee
Number of pages:
148
Published on:
2011-04-01
Stock:
Available
Category:
Clinical disciplines
Price:
59.00 €
Keywords:
Breast Cancer, System Biology, Medicinal Approach, Disease Network, Chemotherapeutic Agents, Antimutagens, systems biology, Disease Forecasting; Evapotranspiration; Precision Farming; Wireless Sensor Network, chemotherapeutic agents

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