Bookcover of Pulmonary embolism pathophysiology and biochemical processes
Booktitle:

Pulmonary embolism pathophysiology and biochemical processes

GlobeEdit (2016-09-02 )

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ISBN-13:

978-3-330-71391-8

ISBN-10:
3330713917
EAN:
9783330713918
Book language:
English
Blurb/Shorttext:
Acute pulmonary embolism is a relatively common disease that may become critical and associated with increased mortality. Several pathophysiological and biochemical processes including increased pressure in pulmonary arteries, increased right ventricular afterload and right ventricular pressure, shear stress, inflammation, oxidative stress, certain cytokines, extracellular matrix remodelling, endogenous vascular elastase, plasminogen activator/plasmin system and MMP-s have been identified as potential factors in the development of pathological changes in acute pulmonary embolism. To extend our knowledge about these processes we conducted four studies using experimental animal models and performed clinical studies on acute pulmonary embolism. In our experiments we investigated the oxidative stress, changes in platelet count and platelet aggregation, changes in MMP and TIMP levels as well as alteration of NO consumption. In our book we present the used materials and methods, describe and discuss our results as well as give conclusions to understand the pathophysiological background of pulmonary embolism induced biochemical changes in experimental models and in the clinical setting.
Publishing house:
GlobeEdit
Website:
https://www.globeedit.com
By (author) :
Diana Mühl, Tamás Kiss
Number of pages:
84
Published on:
2016-09-02
Stock:
Available
Category:
Clinical disciplines
Price:
28.90 €
Keywords:
oxidative stress, Platelet aggregation, Pulmonary Embolism, thrombolysis, matrix metalloproteinase, inhibitor of metalloproteinase, NO consumption, pulmonary hyrertension

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