Bookcover of Product related factors influencing the immunogenicity of interferon B
Booktitle:

Product related factors influencing the immunogenicity of interferon B

LAP LAMBERT Academic Publishing (2016-08-16 )

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ISBN-13:

978-3-659-93462-9

ISBN-10:
3659934623
EAN:
9783659934629
Book language:
English
Blurb/Shorttext:
Therapeutic interferon beta is the first line treatment of relapsing remitting Multiple Sclerosis. However, despite their success in improving patient wellbeing, all IFNβ products encounter a significant problem: immunogenicity. In some patients, IFNβ products induce the formation of antidrug antibodies that undermine treatment efficacy and may even lead to treatment failure. These patients not only have a substantial health risk due to failing treatment, but are being treated with expensive products that no longer work. Developing low or non-immunogenic therapeutic IFNβ products requires an understanding of why these products are immunogenic. Preliminary data suggest several product related factors such as formulation, aggregation and epitopes influencing the immunogenicity of IFNβ-1b. Research described in this book aims to determine which of these potential triggers is causing immunogenicity. Our findings have pushed us one step closer to answering this question.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Mohadeseh Haji Abdolvahab
Number of pages:
296
Published on:
2016-08-16
Stock:
Available
Category:
Medicine
Price:
74.90 €
Keywords:
Aggregation, epitope, Immunogenicity, Product related factor, interferon beta

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