Bookcover of Preparation and evaluation of novel drug alginate granule systems
Booktitle:

Preparation and evaluation of novel drug alginate granule systems

Alginate based drug delivery systems for taste improvement

VDM Verlag Dr. Müller (2009-12-06 )

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ISBN-13:

978-3-639-20332-5

ISBN-10:
3639203321
EAN:
9783639203325
Book language:
English
Blurb/Shorttext:
Oral solid drug particles are sometimes incorporated within a polymer matrix or encapsulated to delay drug release only for short times (60s) to improve taste. They are meant to release the drug once it reaches the stomach to produce the effect. Manufacturing of drug polymer formulations is often limited to the laboratory as they involve use of large amounts of toxic solvents or water which needs to be removed. This makes the process complicated and costly especially if these systems are to be used for taste improvement. This research demonstrates a novel way to prepare a drug polymeric system using paracetamol and alginate as model drug and polymer respectively. The method is simple and scalable at the same time uses very little solvent (water) during manufacture. Physicochemical characterization and sensory evaluation of selected granules screened using a specially designed sub 60s drug release suggest this technology can be used successfully as platform technology for taste improvement in the future. The technology may be extended for other drugs and polymers especially water soluble polymers which can be cross linked using counter ions.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
By (author) :
Debashis Mukhopadhyay
Number of pages:
332
Published on:
2009-12-06
Stock:
Available
Category:
Technology
Price:
79.00 €
Keywords:
Reduced swollen state; Cross linking process; Characterization; Alginates; Factorial design; Mapping of cross linking under dehydrated state; Sub 60s drug release; Sensory response; Correlation; Taste improvement; Modified Block design and Analogue LMS Sc, Reduced swollen state; Cross linking process; Characterization; Alginates; Factorial design; Mapping of cross linking under dehydrated state; Sub 60s drug release; Sensory response; Correlation; Taste improvement; Modified Block design and Analogue LMS

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