Bookcover of P-glycoprotein and the development of multidrug resistance
Booktitle:

P-glycoprotein and the development of multidrug resistance

LAP LAMBERT Academic Publishing (2014-11-07 )

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ISBN-13:

978-3-659-63449-9

ISBN-10:
3659634492
EAN:
9783659634499
Book language:
English
Blurb/Shorttext:
The development of drug resistance during the therapy is a major obstacle in the successful treatment of various pathologies. The in vitro studies on cell lines have shown that exposure to a single drug often leads to a cross-resistance to several other structurally and functionally unrelated compounds. This phenomenon is known as multidrug resistance (multidrug resistance, MDR). The membrane transporters play a role in the absorption, distribution and elimination of metabolic products, of ions and of most drugs. The membrane transporters include a variety of membrane proteins with different structures and functions, such as, for example, exchangers of ions and proteins from the ABC family (ATP-binding cassette). Importance of the membrane transporters appears from genetic diseases that are caused by alteration of their functions. Although the role of membrane transporters in the drug effects aroused a particular interest in the recent years, the relevant transporters remain still unknown to most drugs. Even though it is known that a specific transporter interacts with a drug, there is the possibility that the unidentified transporters to recognize the same drug.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Nicolae Alina
Number of pages:
112
Published on:
2014-11-07
Stock:
Available
Category:
Other
Price:
32.90 €
Keywords:
MdR, P-Glycoprotein

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