Bookcover of Ovarian Cancer Transmesothelial Migration
Booktitle:

Ovarian Cancer Transmesothelial Migration

Individual Cell-Based Model for Single Cells and Spheroids Invasion

LAP LAMBERT Academic Publishing (2012-04-26 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-8484-8128-6

ISBN-10:
3848481286
EAN:
9783848481286
Book language:
English
Blurb/Shorttext:
Ovarian cancer is the leading cause of death among gynecological malignancies. The high mortality rate is essentially due to cell ability to cross the mesothelial lining of the peritoneum and form widespread metastasis. This book illustrates a mathematical model able to reproduce in vitro transmesothelial migration assays of ovarian cancer cells, both isolated and aggregated in multicellular spheroids. The model integrates: (a) an Extended Cellular Potts Model (CPM), that captures mechanisms of cellular adhesion, shape constraints and motion; (b) a continuous model for the diffusion of chemoattractants; (c) a continuous model for matrix metalloproteinases released by tumor cells. The results predicted are in good agreement with biological experiments and they point out the principal biological phenomena and their influence on the overall process of invasion. This analysis could help understanding the potentiality of mathematical models in predicting cellular behaviors and should be especially useful to biologists that want to have a look into possible tools to enhance their researches and to mathematicians interested in applying their knowledge to biological systems
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Chiara Giverso
Number of pages:
148
Published on:
2012-04-26
Stock:
Available
Category:
Biochemistry, biophysics
Price:
59.00 €
Keywords:
ovarian cancer, Cancer cell, Metastasis, Spheroid, transmesothelial migration, individual cell-based model, cellular potts model, peritoneum invasion

Books loader

Newsletter

Adyen::diners Adyen::jcb Adyen::discover Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Adyen::paypal Paypal CryptoWallet Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING