Bookcover of Oro dispersible tablets: Effect of superdisintegrants
Booktitle:

Oro dispersible tablets: Effect of superdisintegrants

LAP LAMBERT Academic Publishing (2015-02-13 )

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ISBN-13:

978-3-659-53780-6

ISBN-10:
3659537802
EAN:
9783659537806
Book language:
English
Blurb/Shorttext:
The purpose of this research was to develop orodispersible tablet of fluoxetine hydrochloride. Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor drug which is used in psychiatric disorder like depression. Orodispersible tablet prepared using various concentrations (1.5%, 3% & 4.5%) of superdisintegrates like crosscarmellose, crospovidone, sodium starch glycolate by wet granulation method & sublimation method. The preformulation studies by FTIR confirmed no interactions between drug and polymers. The prepared formulations were evaluated for the pre-compression parameters & the values were within prescribed limits. The tablets prepared by wet granulation & sublimation method were evaluated for physical parameters, wetting time, disintegration time, content uniformity and in vitro dissolution.Upon comparison sublimation method was showed good results for disintegration time ,wetting time & in vitro drug release studies because sublimation of camphor increases the porosity of the tablets. The tablets prepared with crospovidone at 4.5% concentration (FS-6) by sublimation method was found to be best suitable formulation.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Appapurapu Ashok kumar
Number of pages:
172
Published on:
2015-02-13
Stock:
Available
Category:
Pharmacy
Price:
64.90 €
Keywords:
comparison, immediate release dosage form, wet granualtion, sublimation and superdisintegrants

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