Bookcover of Opiate Dependence
Booktitle:

Opiate Dependence

Focus on the corticotropin-releasing factor system

LAP LAMBERT Academic Publishing (2012-10-23 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-659-28305-5

ISBN-10:
3659283053
EAN:
9783659283055
Book language:
English
Blurb/Shorttext:
Among humans, the emergence of the opiate withdrawal (OW) syndrome after cessation of opiate intake is considered as one of the key motivational elements that lead to the opiates relapse. Through its two receptors: CRF1 and CRF2, The corticotropin-releasing factor (CRF) system is the major coordinator of stress responsive circuitry and has recently emerged as major contributor in the development of components of the OW syndrome. The aim of this thesis is to determine the role of CRF2 receptor in the negative affect and motivational disorders of OW. Here, we reported that genetic deletion of the CRF2 receptor, in mice, eliminates dysphoria and molecular alterations induced by OW without impairing brain, neuroendocrine and autonomic stress-coping responses to withdrawal. In addition, using operant responding to food, we found a crucial role of the CRF2 receptor in the motivational disorders and relapse to food seeking elicited by OW. These findings underscore the importance of CRF2 receptor as possible effective treatment of the critical problem of opiate dependence.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Khalil Adnane Rouibi
Number of pages:
312
Published on:
2012-10-23
Stock:
Available
Category:
Biology
Price:
79.00 €
Keywords:
Opiate dependence; corticotropin releasing factor system; CRF2 receptor pathway; withdrawal; negative affect; anhedonia; motivation; relapse; stress; mouse.

Books loader

Newsletter

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Paypal Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING