Bookcover of Normal and Binding Mode Analysis of Breast Cancer Resistance Protein
Booktitle:

Normal and Binding Mode Analysis of Breast Cancer Resistance Protein

Structural Bioinformatics of BCRP

LAP LAMBERT Academic Publishing (2012-06-09 )

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ISBN-13:

978-3-659-15312-9

ISBN-10:
3659153125
EAN:
9783659153129
Book language:
English
Blurb/Shorttext:
Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific amino acids and its interaction with various synthetic and natural compounds provided clues of developing an efficient inhibitor.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Prasanth Kumar, Saumya Patel, Himanshu Pandya
Number of pages:
104
Published on:
2012-06-09
Stock:
Available
Category:
Informatics
Price:
49.00 €
Keywords:
Breast Cancer, Resistance Protein, Normal Mode Analysis, Binding Mode Analysis, Docking.

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