Bookcover of Non-Genetic Cancer Cell Plasticity
Booktitle:

Non-Genetic Cancer Cell Plasticity

LAP LAMBERT Academic Publishing (2016-05-18 )

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ISBN-13:

978-3-659-82524-8

ISBN-10:
3659825247
EAN:
9783659825248
Book language:
English
Blurb/Shorttext:
The development of drug resistance during treatment is possibly the most important factor hampering the success of cancer therapy. In order to survive in the presence of chemotherapeutic drugs cells must quickly adapt to their altered environment. This may involve a collective stress response of interacting cells, whose mechanism is not yet clear. In the course of this work we interrogated the conceptual framework used to describe cancer and examined different aspects of drug resistance. Here I present the idea that acquired drug resistance is not simply the passive selection of pre-existing mutants but can be accelerated by active adaptation. Cancer treatment is therefore a double-edge sword: while the weakest cells die, the survivors cope cell-autonomously with the therapeutic perturbation.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Angela Oliveira Pisco
Number of pages:
216
Published on:
2016-05-18
Stock:
Available
Category:
Biology
Price:
76.90 €
Keywords:
Cancer, Multi-drug resistance, Epigenetic Landscape

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