Bookcover of Non-canonical pre-TCR signaling during T cell development
Booktitle:

Non-canonical pre-TCR signaling during T cell development

LAP LAMBERT Academic Publishing (2016-03-23 )

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ISBN-13:

978-3-659-85761-4

ISBN-10:
3659857610
EAN:
9783659857614
Book language:
English
Blurb/Shorttext:
T cells undergoing maturation in the thymus need to receive a pre-TCR-delivered signal to undergo β-selection and develop further properly. The pre-TCR is composed of a constitutively expressed pre-Tα (pTα) chain and a de novo expressed TCRβ chain. A productive recombination of the TCRβ chain is mandatory to overcome the first checkpoint that controls T cells survival. However, in a very low but consistent extent, thymocytes lacking a canonical pre-TCR can differentiate further. We show that thymocytes lacking a classical pre-TCR can survive and differentiate to later developmental stages. Besides, signaling through a pTα-less TCR is enough to achieve Ca2+ influx and NF-κB activation. In addition, we demonstrate that the mechanisms underlying cell death of thymocytes in conditions of proteasome inhibition are in great extent independent of NF-κB activation and pre-TCR or TCR signaling, and are rather dependent on triggering the pro-apoptotic terminal UPR.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Damian Maseda Caballero
Number of pages:
104
Published on:
2016-03-23
Stock:
Available
Category:
Biology
Price:
39.90 €
Keywords:
B cell, immunology, inflammation, proteasome, T cell, T cell receptor, Thymus

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