Bookcover of New therapeutic compounds against tuberculosis
Booktitle:

New therapeutic compounds against tuberculosis

In silico design of new therapeutic compounds targeting biosynthetic pathway of Mycolic acid in M. tuberculosis

LAP LAMBERT Academic Publishing (2016-06-21 )

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ISBN-13:

978-3-659-89091-8

ISBN-10:
365989091X
EAN:
9783659890918
Book language:
English
Blurb/Shorttext:
Tuberculosis (TB) proved to be a controllable , preventable and curable disease , but it still remains as a leading cause for mortality. Rational Drug Design (RDD) is basically a computer-aided molecular modeling, it is an iterative process, If it is based on the knowledge of three - dimensional (3-D) structure of the target proteins of interest; it is called “structure based drug design” or “target based drug design”. Such knowledge allows to design molecules capable of binding the receptor so as to maximize the drug affinity and specificity towards the target. Mycolic acid biosynthesis pathway in Mycobacterium tuberculosis was considered a fatal target by designing inhibitors against the enzymes which play a vital role in this pathway.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Asra'a Adnan Abdul-Jalil, Zahra Mahmoud Al-Khafaji
Number of pages:
240
Published on:
2016-06-21
Stock:
Available
Category:
Biology
Price:
76.90 €
Keywords:
CADD, Molecular Docking, Tuerculosis, accD3, primer design, Distance trees, Mycolic acid

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