Neuronal Differentiation of Embryonic Carcinoma Cells

Differential gene expression pattern of key genes during differentiation regime

LAP LAMBERT Academic Publishing (2011-05-17 )

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ISBN-13:: 978-3-8443-9036-0
ISBN-10:: 3844390367
EAN:: 9783844390360
Book language:: English
Blurb/Shorttext:: Embryonic Carcinoma cells (EC) are malignant germ cell tumor that occurs most often in the testes.EC cells serves as a model for studying embryonic development in humans.These cells are pluripotent teratocarcinomas that are derived from transformed germ cells.EC cells are stem cells of such tumors and are generally considered to be the malignant counterparts of ES cells.The NTERA-2 cell line is pluripotent human teratocarcinoma cell.NTERA-2 shares many characteristic with human ES cell. Also, the global expression of these cells is highly similar to undifferentiated hESC expression. NTERA-2 cell as like their human counter part on treatment with Retinoic acid gets differentiated into a mixed population of cell of neuronal lineage. The study aims at monitoring the transcript abundance of genes that have previously been implicated in neuronal differentiation, namely PAX6, NOGGIN, NEUROD and NESTIN and also tries to throw some light on potential differentiation specific candidate.
Publishing house:: LAP LAMBERT Academic Publishing
Website:: https://www.lap-publishing.com/
By (author) :: Ashish Ranjan
Number of pages:: 60
Published on:: 2011-05-17
Stock:: Available
Category:: Biology
Price:: 49.00 €
Keywords:: ES Cell, differentiation, Genetic regulators, Embryonic Carcinoma Cells, Real Time Analysis, Potential New Candidate, Real-Time Analysis