Bookcover of Native Chemical Ligation
Booktitle:

Native Chemical Ligation

Chemical Ligation

VertPress (2012-04-03 )

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ISBN-13:

978-613-8-55456-1

ISBN-10:
6138554566
EAN:
9786138554561
Book language:
English
Blurb/Shorttext:
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Native chemical ligation or NCL is the most widely used form of chemical ligation, a technique for constructing a large polypeptide from two or more unprotected peptides. In native chemical ligation a peptide containing a C-terminal thioester reacts with another peptide containing an N-terminal cysteine residue, in the presence of an added thiol catalyst. In a freely reversible first step, a transthioesterification occurs to yield a thioester-linked intermediate; this intermediate rearranges irreversibly under the usual reaction conditions to form a native amide ('peptide') bond at the ligation site. Native chemical ligation of unprotected peptide segments was developed in the laboratory of Stephen Kent at The Scripps Research Institute in 1994.
Publishing house:
VertPress
Website:
http://www.betascript-publishing.com
Edited by:
Bartholomei Timotheos Crispinus
Number of pages:
68
Published on:
2012-04-03
Stock:
Available
Category:
Chemistry
Price:
29.00 €
Keywords:
Terminal, chemical, Native, Intermediate, Ligation, Rearranges

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