Bookcover of N-RAS gene in Acute Myeloid Leukemia and Myelodysplastic Syndrome
Booktitle:

N-RAS gene in Acute Myeloid Leukemia and Myelodysplastic Syndrome

Scholars' Press (2015-07-09 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-639-76664-6

ISBN-10:
3639766644
EAN:
9783639766646
Book language:
English
Blurb/Shorttext:
N-RAS gene mutations are the most commonly detected molecular abnormalities in hematologic malignancies, especially in those of myeloid origin. RAS proteins possess intrinsic GTPase activity that regulates cellular proliferation by cycling between active guanine triphosphate (GTP bound state) and inactive guanine diphosphate (GDP bound states). Point mutation of N-RAS gene resulting in loss of the intrinsic GTPase activity and RAS proteins locked in an active state (GTP bound state), leading to the uncontrolled, growth factors independent proliferation of hematopoietic progenitors. All point mutations of the N-RAS genes occurred at different nucleotides of codons 12, 13, or 61. Current study aimed to determine the frequency of N-RAS mutation and its correlation with P21N-RAS protein expression, clinical and hematological parameters in patients with acute myeloid leukemia (AML) and Myelodysplastic syndrome (MDS) in Iraq.
Publishing house:
Scholars' Press
Website:
http://www.scholars-press.com
By (author) :
Nahidh Kamel
Number of pages:
184
Published on:
2015-07-09
Stock:
Available
Category:
Medicine
Price:
79.90 €
Keywords:
AML, MDS, MSDA, complete remission, N-RAS, Mutation sensitive digestion analysis, P21N-RAS, Digital analysis, ِِAcute Myeloid Leukemia, Myelodysplastic Syndrome

Books loader

Newsletter

Adyen::diners Adyen::jcb Adyen::discover Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Adyen::paypal Paypal CryptoWallet Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING