Bookcover of Multi-Step Synthesis of Solid Support with Protected 5'-Aminouridine.
Booktitle:

Multi-Step Synthesis of Solid Support with Protected 5'-Aminouridine.

My Research was Focussed on the Multi-Step Synthesis of Solid Support Bearing Modified Nucleoside for Automated Synthesis of siRNAs.

VDM Verlag Dr. Müller (2008-10-15 )

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ISBN-13:

978-3-639-09087-1

ISBN-10:
363909087X
EAN:
9783639090871
Book language:
English
Blurb/Shorttext:
During my M.S. thesis work I was involved in a multistep synthesis of solid support bearing a modified nucleoside for automated synthesis of siRNAs. First, I developed a three-step synthesis of protected 5'-amino uridine from uridine. Next I prepared the 3'-succinate of 5'-amino uridine in a one-pot two-step synthesis and attached it to a solid support via a succinamide linker. I had analyzed and characterized all new compounds using NMR techniques. Others in our laboratory used this solid support for synthesis of amide-modified siRNAs. We anticipate that the amide linkages will facilitate crossing the cellular membrane and improve nuclease resistance, biodistribution and pharmacokinetics of modified siRNAs.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
By (author) :
Suresh Swapna
Number of pages:
60
Published on:
2008-10-15
Stock:
Available
Category:
Chemistry
Price:
49.00 €
Keywords:
Synthetic Organic Chemistry

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