Bookcover of Molecular Dissection of the Clonal M1T1 Group A Streptococci
Booktitle:

Molecular Dissection of the Clonal M1T1 Group A Streptococci

Integrating Genomics, Proteomics, and Bioinformatics Tools to Define the Unique Features of a Pandemic Flesh-Eating Bacterial Strain

VDM Verlag Dr. Müller (2009-10-09 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-639-19659-7

ISBN-10:
3639196597
EAN:
9783639196597
Book language:
English
Blurb/Shorttext:
A particular strain of the group A streptococci (GAS), known as the M1T1 clone, has exhibited unusual epidemiology and virulence, and has been largely associated with the pandemic of invasive GAS infections worldwide. M1T1 was among few GAS strains that have outnumbered other serotypes since the mid-1980s, and their increase in GAS populations coincided with the resurgence of invasive and severe forms of streptococcal diseases, especially the streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (NF). The resurgence of the severe diseases was thus suspected to be a result of an unusual pathogenic potential inherent to the few reemerging strains. This book, based on my PhD dissertation, discusses unique features that may have endowed the global M1T1 clone with its unusual properties, and the genomic and evolutionary basis for its emergence and persistence. Among M1T1's unique features are its ability to switch to a hypervirulent phenotype with a survival advantage in deep tissues; the acquisition and exchange of mosaic prophages that encode novel exotoxins; and the production of the potent DNase Sda1, which frees the bacteria from the leukocyte extracellular traps.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
By (author) :
Ramy Karam Aziz
Number of pages:
164
Published on:
2009-10-09
Stock:
Available
Category:
Microbiology
Price:
68.00 €
Keywords:
microbiology, immunology, microbial evolution, microbial pathogenesis, Bioinformatics, virulence, genomics, pathogenomics, Streptococcus, bacteriophage

Books loader

Newsletter

Adyen::diners Adyen::jcb Adyen::discover Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Adyen::paypal Paypal CryptoWallet Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING