Bookcover of Mixed Solvency Concept
Booktitle:

Mixed Solvency Concept

A Easy method to enhance the solubility & bioavailability of drugs

LAP LAMBERT Academic Publishing (2013-06-19 )

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ISBN-13:

978-3-659-41495-4

ISBN-10:
3659414956
EAN:
9783659414954
Book language:
English
Blurb/Shorttext:
In these investigation conventional piroxicam capsule has slow onset of action (45-60 min) and poor bioavailability (50-60%), and therefore cannot be given in emergency clinical situations like postoperative pain, rheumatoid arthritis or osteoarthritis. So purpose of research was to provide a fast dissolving dosage form of piroxicam, which can provide quick onset of action by using mixed solvency concept. First carried out Initially solubility of piroxicam was determined individually in 3 hydrotropic agents like sodium benzoate, sodium citrate, niacinamide and 4 water soluble polymer namely HPBCD, PVP K30, PEG400, PEG8000 at conc. of 40% w/v solutions using purified water as solvent. Highest solubility was obtained in 40% sodium benzoate solution. Then different combinations of 2, 3 and 4 hydrotropic agents+water soluble polymer in different ratios were used to determine solubility, so that total conc. of solubilizer blend was always 40%. Highest solubility was obtained in solution of sodium benzoate+HP-BCD+PVP K30 at optimum ratio of 15:15:10. This optimized combination was utilized in preparing solid dispersions having enhanced solubility & used for pharmaceutical formulations.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Avinash Mansuk, Kantilal Narkhede, Lukkad Harish
Number of pages:
112
Published on:
2013-06-19
Stock:
Available
Category:
Pharmacy
Price:
54.90 €
Keywords:
solid dispersion, mixed solvency concept

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