Bookcover of Microbial Biotransformation of Ezetimibe
Booktitle:

Microbial Biotransformation of Ezetimibe

Investigations on metabolism of Fluorinated Drugs

LAP LAMBERT Academic Publishing (2016-08-17 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-659-90424-0

ISBN-10:
3659904244
EAN:
9783659904240
Book language:
English
Blurb/Shorttext:
The phenomenon of microbial biotransformation has gained significance regarding imitation of mammalian metabolism of drugs as well as rendering chemical diversity in these compounds via functionalization of unreactive centres enabling further modification of biologically active molecules. This can be attributed mainly to the diverse enzymatic machinery naturally present in microorganisms that transcends limited probability of structural diversity generated via conventional synthetic routes. It is more efficient/cost effective than using microsomal preparations from hepatocytes and raises no ethical issues such as those encountered with the dosing of animals. Another pertinent aspect of microbial biotransformation is bioremediation of hazardous chemicals in environment. Since fluorine atom is present in majority of pharmacological agents contamination of the environment by such compounds is worthy of separate study. This book describes microbial biotransformation of ezetimibe by two different fungi. Fungal enzymes acted on –OH group of propyl carbon as well as lactam ring. This book is useful for research students working in area of drug metabolism/development.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Irfan Pervaiz, Saeed Ahmad
Number of pages:
88
Published on:
2016-08-17
Stock:
Available
Category:
Chemistry
Price:
49.90 €
Keywords:
biotransformation, Cholesterol, Ezetimibe, Fermentation, UDP-Glucuronosyl transferase system, Phase-I Metabolism, Phase-II Metabolism

Books loader

Adyen::diners Adyen::jcb Adyen::discover Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Adyen::paypal Paypal Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING