Bookcover of Microbial aldolases as C-C bonding enzymes
Booktitle:

Microbial aldolases as C-C bonding enzymes

Investigation of structural-functional characteristics and application for stereoselective reactions

VDM Verlag Dr. Müller (2009-09-30 )

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ISBN-13:

978-3-639-20250-2

ISBN-10:
3639202503
EAN:
9783639202502
Book language:
English
Blurb/Shorttext:
Carbon-carbon bonding enzymes can be attractive alternatives to standard chemical methods by allowing chiral control, taking advantage of mild reaction conditions and minimizing the use of protecting groups in reactions. Fructose-6-phosphate aldolase (FSA) from Escherichia coli catalyses reversibly the cleavage of D-fructose-6-phosphate into dihydroxyacetone (DHA) and D-glyceraldehyde-3-phosphate (GAP). In addition, the enzyme creates new building blocks with 3S, 4R configuration by use of DHA as donor and various aldehydes as acceptor. The goal of this work was to investigate FSA and compare it with the transaldolase from Bacillus subtilis (TALBsu) which is similar both in sequence and structure to FSA (30% identical in amino acid residues). This should help to elucidate relationships between structure and function of both enzymes, and possible applications for FSA and TALBsu for the production of valuable sugars or sugar derivatives.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
By (author) :
Tomoyuki Inoue
Number of pages:
140
Published on:
2009-09-30
Stock:
Available
Category:
Biochemistry, biophysics
Price:
2,089.19 NT$
Keywords:
C-C bonding enzyme, E.coli, aldolase, structural-functional characteristic, stereoselective reaction, FSA, TAL, fructose-6-phosphate

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