Bookcover of Long Span DNA-PET for Unravelling Cancer Genomic Rearrangements
Booktitle:

Long Span DNA-PET for Unravelling Cancer Genomic Rearrangements

Applying 10 kb DNA-PET technology to cancer genomes for identifying driver genomic rearrangements

LAP LAMBERT Academic Publishing (2016-10-21 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-659-93544-2

ISBN-10:
3659935441
EAN:
9783659935442
Book language:
English
Blurb/Shorttext:
All cancers are the result of changes occurred in the DNA sequence of the genomes of cancer cells. We have learned much about these mutations and the abnormal genes that operate in human cancers in the last several decades. Now, we are moving to the new era in which the complete DNA sequence of cancer genomes can be achieved with the help of the next generation sequencing technologies. In this study, by comparing the large insert libraries (10-20 kb) with short insert (1 kb) libraries, we show that large inserts are superior to short inserts in providing higher physical genome coverage and therefore achieve greater sensitivity for the identification of the different types of SVs, including copy number neutral and complex events. Applying the 10 kb DNA-PET technology to 15 cancer genomes, including both primary tumors and cancer cell lines, we show some important genomic characteristics in breast and gastric cancer genomes. With its versatile and powerful nature, the long span DNA-PET sequencing technology has a bright future ahead in studying the structures of numerous normal and cancer genomes.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Fei Yao
Number of pages:
180
Published on:
2016-10-21
Stock:
Available
Category:
Biology
Price:
64.90 €
Keywords:
Mutations, next generation sequencing, DAN-PET, cancer genome, genomic rearrangement

Books loader

Newsletter

Adyen::diners Adyen::jcb Adyen::discover Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::alipay Adyen::unionpay Adyen::paypal Paypal CryptoWallet Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING