Bookcover of Investigation of the Molecular Mechanisms of α,β-unsaturated Compounds
Booktitle:

Investigation of the Molecular Mechanisms of α,β-unsaturated Compounds

LAP LAMBERT Academic Publishing (2012-12-17 )

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ISBN-13:

978-3-659-27300-1

ISBN-10:
3659273007
EAN:
9783659273001
Book language:
English
Blurb/Shorttext:
Glutathione S-transferase GSTπ has been one of the significant targets for cancer treatment in the past several years. The reason behind that is 1) its overexpression in some cancer cells compared to normal ones 2) its ability to cause resistance against cancer chemotherapeutics and 3) its protective role against reactive oxygen species (ROS). We have synthesized a large number of compounds which have strong potency against different cancer cell lines. These compounds possess a 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore. In the present study some investigations as to the way in which cytotoxicity is mediated was undertaken. Our results have demonstrated that the analogs NC 2067 and NC 2081 behaved as substrates for GSTπ and reduced the level of GSH. This was apparent by the decrease in the concentrations of both compounds after the addition of GSTπ and GSH. In addition, both agents caused about 3-7 folds increase in ROS levels. The dichlorodihydrofluorescein dye was used for this purpose due to its fluorescence characteristic after being oxidized by ROS.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Muath Helal
Number of pages:
104
Published on:
2012-12-17
Stock:
Available
Category:
Biology
Price:
49.00 €
Keywords:
mitochondria, reactive oxygen species, cytotoxicity, glutathione, mitochondrial membrane potential

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